Liquid-liquid chromatography made easy
Understand liquid-liquid chromatography easily
RotaChrom's new white paper, "Advanced Chromatography," delves deeper into the intricacies of centrifugal partition chromatography (CPC) and liquid liquid chromatography. Building upon the basic concepts outlined in our previous paper, "An Introduction to Chromatography," this new guide aims to make CPC accessible to a wider audience, even those without a background in science or chemistry.
The goal is to make CPC a an easy to understand topic so anyone, even without a degree in science or chemistry, could understand the subject. We divided the topics into specific chapters, each dealing with a few aspects of CPC.
Liquid-liquid chromatography
Liquid liquid chromatography is a combination of liquid liquid separation principles combined with the methodology of chromatography. In this technique, separation occurs between two immiscible liquid phases, as both the mobile and stationary phases are liquids.
In an LLC system separation takes place based on the differing partitioning behavior of the solutes between the two phases. Since LLC uses a liquid stationary phase, the technique offers many advantages over traditional liquid-solid chromatographic separation techniques, and can easily be scaled up to preparative liquid chromatography.
Download your full white paper here.
To help you in your chromatographic journey, we would like to offer you a free white paper which includes all the knowledge about CPC and its many aspects that our team of qualified experts collected throughout the years.
Please complete the form below to download your free white paper.
Advantages of LLC
Advantages of liquid liquid chromatography include:
- No need for silica gel, which cuts the cost of consumables and removes a polluting and expensive material from the process
- Silica degradation is not an issue
- No need for silica regeneration cycle or replacement
- High sample loading capacity
- The possibility of lossless sample recovery
- Separation of any compound that is soluble in a liquid phase
- Quick and simple method development, with predictable outcomes
Read more about LLC's advantages in the white paper.
RotaChrom brings industrial-scale CPC solutions to businesses, researchers, CROs and CDMOs
What you have seen so far is just the tip of the iceberg.
If you'd like to dive deeper, please fill in the form above, and grab your free copy of RotaChrom's 'Advanced Chromatography' white paper. The paper covers 4 in-depth chapters about CPC and LLC.
RotaChrom Technologies developed the world’s first industrial scale centrifugal partition chromatography technology solution. These liquid chromatography machines revolutionized purification by providing innovative, sustainable, and efficient industrial scale LC-CPC chromatography to customers all over the world in various industries, including pharmaceutical, nutraceutical and botanical extracts.
RotaChrom’s proven GMP compliant CPC designs are effective solutions when looking for a high-purity, high-capacity, cost-effective and environmentally conscious solution. RotaChrom, with its in-house research laboratory employing world class PhD chemists, engineers and leading business professionals on multiple continents, is the best partner in purification.
Our portfolio includes several products, which can help you scale your business from research to industry. Select between lab scale, pilot scale or industrial scale purification:
- The rCPC platform for pilot-scale purification tasks within a laboratory environment. It is ideal for all batch sizes, smaller or larger, or campaign type of research work, and continuous-batch production.
- The iCPC platform, which is the largest commercially available centrifugal partition Chromatography instrument in the world. It is designed for industrial-scale purification projects in continuous batch operation mode.
