Unlock the full value of Turmeric?
Curcuminoids, such as curcumin, demethoxycurcumin, and bisdemethoxycurcumin, are the bioactive pigments behind turmeric’s antioxidant and anti-inflammatory benefits. While crude extracts are common, advanced nutraceutical and pharmaceutical applications demand high-purity, standardized compounds for:
- Dose consistency & clinical accuracy
- Targeted biological activity
- Regulatory compliance
- Removal of oils, starches, sugars, and other matrix impurities
CPC is a liquid–liquid chromatographic technique with no solid stationary phase. Two immiscible liquid phases are used: one retained by centrifugal force, the other pumped through as the mobile phase.
Two-Stage strategy are used during the purification
Stage 1 — Bulk Purification (Elution Mode CPC):
- Removes major matrix components (lipids, oils, starches)
- Produces a high-purity total curcuminoid mixture (~92.6%)
- >90% recovery
- Ideal for nutraceutical and food additive production
Stage 2 — Individual Isolation (pH-Zone Refining CPC):
- Separates curcumin analogues by their pKa and hydrophobicity
- Delivers concentrated, rectangular peaks with minimal overlap
Results
- Curcumin: 97% purity (87% recovery)
- Demethoxycurcumin: 79% purity (86% recovery)
- Bisdemethoxycurcumin: 93% purity (94% recovery)
Benefits of CPC
Solution for Industrial Curcuminoid Purification
Whether you need bulk curcuminoid mixtures or ultra-pure individual analogues, RotaChrom CPC provides the efficiency, scalability, and compliance required for modern production.
Scalable from Lab to Industry
CPC systems offer true linear scalability — methods developed at pilot scale can be transferred directly to industrial production by proportionally increasing flow rate and injection volume.
Seamless scalability
Allowing methods developed at pilot scale to be transferred directly to manufacturing without costly re-optimization or process disruption
Sensitive or strongly interacting molecules
RotaChrom CPC systems offer true linear scalability — methods developed at pilot scale can be transferred directly to industrial production by proportionally increasing flow rate and injection volume.
Delivers high-purity curcuminoids with exceptional recovery,
Valuable active compounds are not lost during processing and that every batch meets strict quality and performance standards.
Regulated nutraceutical and pharmaceutical manufacturing environment
With robust, reproducible and GMP-ready operation that ensures compliance, reliability, and long-term process stability
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What do you find in this application note?
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Two-stage CPC strategy for high-purity curcuminoid purification
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Bulk matrix removal using elution mode CPC
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Individual curcuminoid isolation with pH-zone refining
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Scalable purification from pilot to industrial production
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High recovery and cost-efficient processing without solid stationary phases
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About RotaChrom
RotaChrom Technologies develops and manufactures industrial-scale centrifugal partition chromatography (CPC) technology platforms. Founded in 2014, RotaChrom distributes its CPC devices around the world. With the help of their industry-leading chemists and engineers, their instruments revolutionized purification by providing cost-effective industrial-scale chromatography solutions to customers in various industries, including pharmaceutical, biotechnology, chemistry, nutraceutical, and botanical extracts.