Continuous manufacturing with Dual-Rotor Centrifugal Partition Chromatography

The Continuous CPC is an advanced liquid–liquid chromatography platform designed for uninterrupted, high-throughput purification. Built on two interconnected GMP-rCPC units operating in dual-mode, dual-rotor configuration (MDM-CPC), it enables continuous compound injection, seamless fraction collection, and continuous manufacturing of chemical compounds. This setup drastically boosts productivity compared to batch-mode systems, while also reducing downtime, lowering solvent and energy consumption, minimizing manual intervention, and increasing overall process efficiency. The result is a robust, scalable platform ideal for cost-effective continuous manufacturing in pharma, biotech, and chemical applications. 

Unmatched Productivity in a Compact Footprint 

By maintaining constant flow and alternating retention cycles, the Continuous CPC eliminates downtime between runs. This enables multiple-fold increases in throughput, with lower solvent consumption and minimal operator intervention. 

Smart Solvent Handling and Modular Design 

An optional on-demand solvent handling system simplifies preparation and recovery. The entire platform is adaptable to project-specific requirements, with customizable modules and robust automation for demanding environments. 

Built for R&D and Industrial Use 

Available in two configurations — Research & Development and Industrial Production — the platform is fully compliant with GMP, ATEX/IECEx Zone 2 standards, and supports validated cleaning procedures. The system holds CE, UKCA, and UL/CSA/NRTL certifications.

Benefits of CPC in continuous process chromatography

Effortless Scale-Up for Higher Production Volumes

Without batch-related constraints, Continuous CPC enables a disruption-free process, simplifying scale-up efforts even in industrial environments with high-load downstream processes.

Exceptionally High Purity

MDM-CPC delivers high-purity compounds with no overlapping peaks, ensuring precise separation, isolation, and remediation, including the removal of contaminants and byproducts.

Seamless, Nonstop Production

Continuous operation eliminates frequent start-ups and shutdowns, providing consistent sample loading and automated process control, reducing human error and ensuring a steady, uninterrupted workflow.

Smaller Footprint, Higher Efficiency

Compared to traditional chromatography systems, Continuous CPC requires less space while offering higher throughput, allowing greater production capacity without expanding facility requirements.

Advanced Purification for Complex Compounds

With its liquid-liquid nature, CPC enables efficient purification of challenging compounds by allowing customized biphasic solvent systems tailored to the target compound’s unique solubility and chemical properties.

Lower CAPEX & OPEX

• No need for silica gel, cartridges, or frequent restarts
• Reduced solvent consumption with effective recycling
• 3x higher productivity than batch processing
• Lower costs compared to MCSGP and SMB
• Resin-free purification for industrial-scale applications

FREE BROCHURE DOWNLOAD

Continuous Chiral Separation in Practice 

New Results Published in Separation and Purification Technology 

A cyclodextrin-mediated chiral CPC (centrifugal partition chromatography) process was developed for rac-voriconazole and successfully intensified from batch to cyclic continuous and continuous MDM (multiple dual mode) operation using Continuous CPC.

Recent results (A. Kiss, D. Rutterschmid, S. Muráth. Sep. Purif. Technol. 2026) demonstrate that chiral separation can be successfully transitioned from batch to continuous operation, overcoming key limitations of traditional approaches. Using centrifugal partition chromatography (CPC), continuous processing enables high-resolution enantioseparation while maintaining consistent product quality.

Moving to continuous operation significantly increases productivity and process efficiency, making chiral purification more viable at industrial scale. In a representative case, continuous CPC delivered up to 99.9% enantiomeric purity alongside an approximately 25-fold increase in productivity compared to classical resolution methods.

Importantly, these gains are achieved without compromising robustness, highlighting the suitability of continuous CPC for demanding separations. The approach also simplifies processing by eliminating unnecessary steps, supporting a more streamlined and scalable workflow.

While selector systems such as cyclodextrins can play a role in enabling enantioselectivity, the key advancement lies in the ability to operate chiral separations in a truly continuous and productivity-driven mode.

Together, continuous CPC provides a practical and scalable solution for industrial chiral purification, combining high performance with significantly improved throughput.

Oligonucleotide isolation

For industrial-scale production of oligonucleotides crucial in vaccine development and pharmacology, CPC can do it in a single purification step.

Purification of isomers

CPC can purify chiral compounds, epimers and diastereomeres (e.g. remdesivir). Purification can easily be scaled up to industrial-scale compared tot raditional chromatographic solutions.

Lipid nanoparticle purification

Lipid nanoparticles (LNPs) are crucial components in mRNA vaccine formulation in pharmaceutical drug delivery research, consisting of key lipid components. CPC can not only ensures the stability of the target lipid but also outperforms traditional chromatography techniques in terms of purity and yield.

Alkaloid remediation

Flow chemistry

Flow chemistry, also referred to as continuous flow, involves conducting chemical reactions within a continuous flow stream. CPC can be integrated into a downstream purification process needed for a flow chemistry operation, and the system can benefit from the advantages of both constituents.