CPC Cell Design Explained
Centrifugal partition chromatography cell design, explained
‘Advanced Chromatography’ is RotaChrom’s series exploring the more in-depth aspects of centrifugal partition chromatography (CPC). It builds upon the foundations in 'An Introduction to Chromatography', but focuses more on CPC and liquid liquid chromatography.
The goal is to make CPC a an easy to understand topic, so anyone, even without a degree in science or chemistry could understand the subject. We divided the bigger topics into specific chapters, each dealing with a few aspects of CPC.
Chromatography without a column
A major difference between preparative high performance liquid chromatography and CPC is the column - or rather the absence of a classic column in CPC. To examine CPC’s cell design, we will explore how RotaChrom Technologies uses its CPC cell and what advantages it has over traditional chromatographic solutions.
The column in a RotaChrom CPC machine is the rotor and the interconnected cells. This is the feature which allows the mahchine to operate in two modes: ascending and descending. This is because a liquid mobile phase can be denser or less dense depending on the separation.
The mobile phase’s density is of course in comparison to the density of the immobilized stationary phase. This means that the mobile phase must be denser or less dense than the stationary phase.
Download your full white paper here.
To help you in your chromatographic journey, we would like to offer you a free white paper which includes all the knowledge about CPC and its many aspects that our team of qualified experts collected throughout the years.
Please complete the form below to download your free white paper.
Advantages of CPC cells
RotaChrom’s CPC design takes advantage of the space provided by cylindrical chambers. Large bore cylinders are easy to manufacture and provide linear scalability thanks to their unique, patented dimensions and architecture.
This unique cell design lets you scale your purification from research to industry. The individual extractions cells are designed in a way that the performance is not impacted, allowing our extraction cells to be scaled from 10 to 100 millimeters without impacting performance and providing flow increases from milliliters per minute to hundreds of milliliters per minute.
Select the perfect device for lab-scale, pilot-scale or industrial-scale purification, and linear scale-up your production from mg to kg/day.
RotaChrom brings industrial scale CPC solutions to businesses and researchers
What you have seen so far is just the tip of the iceberg.
If you'd like to dive deeper, please fill in the form above, and grab your free copy of RotaChrom's 'Advanced Chromatography' white paper. The paper covers 4 in-depth chapters about CPC and LLC.
RotaChrom Technologies developed the world’s first industrial scale centrifugal partiton chromatography technology solution. These liquid chromatography machines revolutionized purification by providing innovative, sustainable, and efficient industrial scale LC-CPC chromatography to customers all over the world in various industries, including pharmaceutical, nutraceutical and botanical extracts.
RotaChrom’s CPC platforms are effective solutions when looking for a high-purity, high-capacity, cost-effective and environmentally conscious solution. RotaChrom, with its in-house research laboratory employing world class PhD chemists, engineers and leading business professionals on multiple continents, is the best partner in purification.
Our portfolio includes:
- The rCPC platform for pilot scale purification tasks within a laboratory environment. It is ideal for all batch sizes, smaller or larger, or campaign type of research work, and continuous-batch production.
- The iCPC platform, which is the largest commercially available centrifugal partition chromatography instrument in the world. It is designed for industrial scale purification projects in continuous batch operation mode.
