Digitally Powered benchtop-sized Method Development in Chromatography 

[ CPC Modeler ]

The CPC Modeler is a compact, desktop-sized, research-scale platform based on liquid–liquid chromatography (Centrifugal Partition Chromatography, CPC), designed to accelerate method development and streamline your transition to production-scale purification. It integrates an intuitive digital toolkit, the CPC Simulator, to model purification strategy, then test and refine it on a small CPC system, the Benchtop CPC, ensuring operational efficiency. The platform also enables seamless scalability to production-level purification without re-engineering across your downstream workflow. Digitally simulate, physically validate, and Seamlessly Scale Up.

Accelerate Method Development with a benchtop device and an In-Silico Simulation for R&D

At its core, the Benchtop CPC enables loading capacities from milligrams to grams per cycle, offering hands-on testing of your purification process. Paired with the CPCSimulator, it allows you to explore solvent systems, estimate partition coefficients, predict method efficiency, and assess overall productivity for your Compounds of Interest (CoIs).

Scale-Up made Simple: From Milligrams to Manufacturing Without Changing Your Method

The system is ideal for purifying APIs, natural extracts, fine chemicals, agrochemical intermediates, and other CoIs, from early-stage R&D to pilot-scale operations. It also serves as an entry point for seamless scale-up to high-throughput production using the same CPC principles.

Built for Compliance and Industry Standards

Built to meet industry standards including GMP, ASME BPE, GAMP, and 21 CFR Part11, the CPC Modeler features a sanitary 316L stainless steel flow path, FDA-compliant wetted parts, and full CE, UKCA, and NRTL certifications.

Benefits of CPC Modeler

End-to-End CPC Method Development

Develop, optimize, and scale CPC methods within a single, fully integrated platform. From lab to industrial scale, CPC supports every step of your downstream purification workflow.

Faster Development, Faster Decisions

Automated process steps and performance modeling significantly shorten development timelines. This enables swift turnaround and helps meet demanding industry expectations.

Broad Solvent and Application Versatility

Work with a wide range of solvent systems and orthogonal separation strategies. CPC supports diverse compounds of interest, even within complex natural or biotechnological matrices.

Flexible and User-Centric Operation

A customizable user interface streamlines method development while offering the flexibility to adapt workflows to specific process needs and compound properties. 

Seamless Scale-Up with One Technology

Move confidently from development to production using the same CPC technology. No need to invest in multiple purification platforms for different downstream steps.

Lower Costs and Reduced Environmental Impact

Liquid–liquid separation eliminates solid stationary phases, reducing consumable costs and solvent waste. Integrated solvent handling, recycling, and recovery further improve sustainability and operational efficiency.

CPCModeler
CPC_Modeler_side
Benchtop CPC
CPCModeler_table

FREE BROCHURE DOWNLOAD

Applications

In the field of downstream processing and bio-manufacturing, Centrifugal Partition Chromatography (CPC) is a versatile and highly efficient separation method. It provides high-resolution separation, exceptional productivity, and superior purity for binary mixtures while also offering a unique solution for the separation of chiral compounds, lipid nanoparticles, oligonucleotides, and proteins. 

 

Oligonucleotide isolation

For industrial-scale production of oligonucleotides crucial in vaccine development and pharmacology, CPC can do it in a single purification step.

Purification of isomers

CPC can purify chiral compounds, epimers and diastereomeres (e.g. remdesivir). Purification can easily be scaled up to industrial-scale compared tot raditional chromatographic solutions.

Lipid nanoparticle purification

Lipid nanoparticles (LNPs) are crucial components in mRNA vaccine formulation in pharmaceutical drug delivery research, consisting of key lipid components. CPC can not only ensures the stability of the target lipid but also outperforms traditional chromatography techniques in terms of purity and yield.

 

Alkaloid remediation

Using RotaChrom’s CPC method and solvent recycling system, you can achieve an increase of 4-5x orders of magnitude in throughput during alkaloid-remediation.
 
Peptides and proteins
 
CPC technology has the transformative potential in revolutionizing purification processes of oligopeptides and large proteins in pharmaceutical industries.

Flow chemistry

Flow chemistry, also referred to as continuous flow, involves conducting chemical reactions within a continuous flow stream. CPC can be integrated into a downstream purification process needed for a flow chemistry operation, and the system can benefit from the advantages of both constituents.

 

About CPC

CPC is a liquid-liquid preparative chromatographic technique, in which separation occurs between two immiscible liquid solvent systems: acting as both the stationary and mobile phases. The liquid stationary phase is immobilized by a strong centrifugal force inside cells attached to a rotor, and the mobile phase is then pumped through the stationary phase in the form of tiny droplets. Separation of the injected sample is based on the sample component’s varying partition coefficients between the mobile and stationary phases. CPC has several advantages like low operational expenses, easy scalability, elimination of sample loss and irreversible adsorption, operation without silica gel or any solid stationary phase, and the possibility to separate a wide array of compounds. 

 

About RotaChrom

RotaChrom Technologies develops and manufactures industrial-scale centrifugal partition chromatography (CPC) technology platforms. Founded in 2014, RotaChrom distributes its CPC devices around the world. With the help of their industry-leading chemists and engineers, their instruments revolutionized purification by providing cost-effective industrial-scale chromatography solutions to customers in various industries, including pharmaceutical, biotechnology, chemistry, nutraceutical, and botanical extracts.

 

 

 

 

Contact RotaChrom

If you have any questions or would like to talk to one of our experts, feel free to contact us by filling the form on the right.
Cookie Policy  /  Data Protection Policy   / RotaChrom® is a registered trademark of RotaChrom Technologies in the USA and EU. All rights reserved. /  © 2023 RotaChrom Technologies. All rights reserved.