Production-Scale Chromatography Platform with Integrated Solvent Management  

The pCPC platform is RotaChrom’s most powerful solution for industrial-scale purification. It integrates the world’s largest commercially available Centrifugal Partition Chromatography (CPC) instrument, the iCPC, with a fully automated solvent preparation, recovery, and regeneration system, forming a complete and turnkey production platform. The system is controlled via a PLC (Programmable Logic Controller), which ensures precise parameter tuning, allows for integration with multiple devices, and supports real-time process automation. 

Industrial-scale Throughput, Outstanding Purity and Yield 

With its exceptional productivity, the pCPC platform is purpose-built for demanding industrial environments where high-throughput, cost-efficiency, and regulatory compliance are essential. Capable of processing hundreds of kilograms of crude input material per month, it is an ideal solution for sectors such as pharmaceutical manufacturing, natural product purification, fine chemical production, and agrochemical processing. 

It delivers exceptional throughput, while maintaining the same relative resolution and load efficiency as RotaChrom’s pilot-scale rCPC system — making it ideal for high-volume purification tasks where consistency and performance are critical. 

Flexible Multi-Skid Integration for Tailored Industrial Production 

Thanks to its PLC-controlled automation system, the iCPC platform supports a wide variety of customizable skid configurations to match specific production needs. Whether the process requires multiple purification lines, integrated solvent handling units, or additional process modules, the system can synchronize and manage multiple skids in real time, ensuring coordinated and efficient operation. This flexibility makes the iCPC an adaptable solution for complex industrial environments, from pharmaceutical and fine chemical manufacturing to botanical extract processing and beyond.  

Seamless Scale-Up for Industrial Purification  

The pCPC preserves the technical foundation of our pilot-scale rCPC platform but scales it for industrial production. This technological continuity allows users to seamlessly transition from method development or pilot-scale operations to high-capacity manufacturing without revalidating their purification strategy. By utilizing the same CPC principles, workflows developed on the rCPC can be directly transferred to the iCPC, dramatically reducing time, cost, and risk during scale-up. Its PLC-controlled automation system enables precise process control, real-time monitoring, and synchronization of multiple skid units, ensuring stable and efficient operation at full industrial scale. 

Built for Compliance and Cost-Effective Operation 

Designed for industrial longevity, the iCPC is built from 316L stainless steel and PEEK components, ensuring compatibility even with pharmaceutical-grade standards. It’s fully compliant with GMP, ATEX safety standards, and integrates smoothly into regulated manufacturing environments.  

Benefits of the complex iCPC system

Methodology and Scalability

RotaChrom’s Centrifugal Partition Chromatography (CPC) industrial platform addresses these needs by utilizing simplicity in separation mechanism, which offers an easy method development and seamless scale-up.

Purity Standards

Utilizing high-performance cell designs, the system enables isolate target compounds to > 99% purity, meeting the stringent requirements of pharmaceutical and fine chemical applications.

Loading Performance

The iCPC platform demonstrates industry-leading loadability, accommodating high loading capacities of up to 1200 g per cycle.

Industrial Throughput

Engineered for high-volume manufacturing, the system achieves a robust throughput of 20 kg per day, supporting continuous-batch operation for large-scale purification projects. 

System Functionality and Sustainability

Through the continuous extension of system functionalities, the platform capable of reclaiming up to 90% of solvents from both mobile and stationary phases, drastically reducing the environmental footprint.

True Cost-Effectiveness

RotaChrom provides cost-effectiveness, through the extension of system functionalities, the iCPC  not just reducing waste but your operational expenses.

Oligonucleotide isolation

For industrial-scale production of oligonucleotides crucial in vaccine development and pharmacology, CPC can do it in a single purification step.

Purification of isomers

CPC can purify chiral compounds, epimers and diastereomeres (e.g. remdesivir). Purification can easily be scaled up to industrial-scale compared tot raditional chromatographic solutions.

Lipid nanoparticle purification

Lipid nanoparticles (LNPs) are crucial components in mRNA vaccine formulation in pharmaceutical drug delivery research, consisting of key lipid components. CPC can not only ensures the stability of the target lipid but also outperforms traditional chromatography techniques in terms of purity and yield.

Alkaloid remediation

Flow chemistry

Flow chemistry, also referred to as continuous flow, involves conducting chemical reactions within a continuous flow stream. CPC can be integrated into a downstream purification process needed for a flow chemistry operation, and the system can benefit from the advantages of both constituents.