Purification Method Development Platform
The CPC Modeler is a desktop-sized CPC platform, which combines an intuitive method development engine with tailor made semi-preparative chromatographic equipment.
The CPC Modeler predicts, tests, and validates the most effective purification method of different Compounds of Interest (CoI), while also offering the possibility to scale-up production. The platform offers a mg to g/cycle loading capacity and can purify all the compounds that the rCPC can, including pharmaceutical APIs and natural extracts.
One Platform, Two Solutions
Predict
Benefit from an exclusive digital library for easy method development:
- Conduct a chemical similarity-based query for the Compound of Interest (CoI).
- See the recommendation for an appropriate solvent system and purification method.
- Model and optimize purification performance for enhanced efficiency.
- Provide support for seamless scale-up of purification processes.
- Simulate the outcome of the separation before going to the lab.
Validate
Semi-preparative chromatographic equipment capabilities:
- Fine-tune operational parameters for optimal performance.
- Deliver purified materials through the chromatographic process.
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Chromatography on Your Benchtop
The platform consists of three devices:
- The Benchtop CPC: A laboratory-scale CPC device with a mg to g/cycle loading capacity.
- The CPC Simulator: Software solution to predict and visualize purification outcomes.
- Liquid delivery and detection devices: Fraction collection, detection and liquid delivery devices.
Benchtop CPC
The Benchtop CPC is RotaChrom’s laboratory-scale centrifugal partition chromatography device. It is an integral part of the CPC Modeler platform, and as such, this is the device which carries out the chromatographic separations.
The device is based on RotaChrom’s CPC technology, with a customized rotor design outfitted with liquid delivery and detection devices and a fraction collector. As its name suggests, the device can fit on top of a standard desk, making it ideal for laboratory-scale method development tasks.
The Benchtop CPC offers mg to grams scale/cycle loading capacity, and can purify a wide variety of pharmaceutical APIs, natural extracts, stereoisomers and further complex matrices.
Advantages
• Achieve fully integrated method development and solvent screening for RotaChrom’s preparative CPC technique. From lab-scale to industrial-scale, CPC will be there to
support you every step in your downstream process.
• Meet industry expectations with swift turnaround times facilitated by automated process steps.
• Decrease development time and minimize consumable expenses.
• Streamline method development with a customizable User Interface for enhanced flexibility.
• Support drug discovery for compounds sourced from natural and biotechnological origins, navigating through complex matrices. Additionally, explore uncharted chemical spaces for drug-like target molecules.
Benefits
• Model and optimize purification performance for fast and reliable method development.
• Ensure successful and easy method development and scale-up with one purification platform and technology. No need to buy different technologies for each downstream
step.
• Easy, straightforward scalability thanks to RotaChrom’s cell design and CPC’s nature.
• Large variety on solvent systems and orthogonality.
• Select between versatile purification and solvent systems to work with a wide range of COIs.
• Decrease your expenses due to solvent and stationary phase use, thanks to CPC’s liquid-liquid separation techniques, produce less waste with a versatile solvent handling, recycling, and recovery system.
CPC Simulator
The CPC Simulator tool, as the part of the CPC Modeler, and as an individual tool, lets you find the most effective CPC purification method and evaluate the productivity of your compound of interest. The core of the CPC Simulator consists of a database containing extensive data from scientific literature and a search engine that offers you purification methods tested with CPC.
The simulator lets you select between predefined instruments and separation modes. Several important factors affecting peak shape and separation performance are considered in the model calculations to improve the simulator’s predictivity.
Features
• Effective solvent system and purification method development for CPC.
• Only two input data needed for operation: partition coefficient and composition of the crude material.
• Purification performance can be modelled, tested and optimized.
• Thousands of compounds can be tested in silico to find future directions.
• A library of data from scientific literature available, combined with an intelligent search engine, developed by chemists and chemo-informatic experts, highly acknowledged in chromatography.
Benefits
• Quick and cost-effective computational tests instead of slow, cumbersome and expensive experimentation.
• A library of extensive, well-researched and evolving data, instead of time-consuming literature search.
• Precise elution profile with estimation.
• Prediction-based results to support decision making.
CPC Visualizer
The CPC Visualizer is a predictive tool developed by RotaChrom, which can help you predict and visualize the CPC elution profile of a crude material without lab equipment.
Using the built-in separation scenarios and predefined instrument settings the application can be used to get a better understanding of the concepts of the examined CPC separation. After inputting the composition of a crude material and the partition coefficients in a selected solvent system, the application helps you predict if the planned CPC separation will be successful or not without using any laboratory equipment.
The CPC Simulator gives you access to a database based on 16000 entries of scientific publications, solvent system examples, compound data and in-house research to help
you develop the right solvent system and method for your purification goals.
The database lets you to simulate the purification results of 2700 compounds. Each compound comes with several different solvent system combinations allowing you to choose the one most suitable for you purification circumstances and needs.
The database contains an exceptionally large library about natural extracts and compounds. Besides the publications and research, the CPC Simulator’s database comes with a detailed API set, so you can simulate and visualize API purifications.
The database gives you access to in-depth data on compound chemistry, and can help you predict and simulate purification outcomes based on your input.
The database contains information about common CPC solvent systems and compounds that can be purified with them. Solvent system polarity is marked on the ASSPI scale, while molecule polarity is marked on the logP scale. The points on the diagram show matching points where a solvent system can successfully resolve a compound based on scientific data.
