Mother Nature, or the Ultimate Medicinal Chemist
Medicinal plants and crops were always in special focus. Their studied and described positive effects on health existed way before modern medicine, and even today they still coexist, often as a preferred way of treatment.
Companies, focusing on plant-based products tend to acquire a relatively broad-spectrum product that fulfilled its purpose over hundreds of years as medicine or as a food supplement.
Downstream efforts going beyond extraction are rarely used in this industry. However, the current trend shows, especially in pharmaceutical crops and nutraceuticals, that isolation using chromatography is a necessary step toward clean isolates.
Isolating individual compounds often yields high-value materials, that can be further processed into APIs, or can serve as intermediates for further high-value targets. Trends also show that isolates of fractionated constituents derived from natural extracts are often preferred in previously synthetic-dominant environments.
Centrifugal partition chromatography offers many benefits, which are of particular interest to the natural product industry, as it:
- Offers a variety of solvent options, providing researchers with considerable flexibility.
- Allows for the separation of common matrix materials from the specific target analytes.
- Often achieves a high sample recovery rate, ensuring that a significant portion of the sample is successfully obtained.
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Simplify Isolation: Isolate Valuable Compounds Directly
Several natural extracts contain valuable compounds that producers want to utilize in their products. However, these components are often accompanied by other less desirable components, from which the more valuable ones are difficult to isolate.
Compounds, such as Artemisinin, Cyclosporine A, Docetaxel and Digoxin require some form of a purification step in the downstream process chain to be produced in a pure form.
Centrifugal partition chromatography offers many benefits for isolation and is capable of isolating valuable compounds directly from a complex matrix, therefore eliminating further purification steps, like HPLC.
Clearing Nature's Remedies: Efficient Methods to Remove Toxic Impurities
Certain natural extracts, such as the extracts of comfrey, red clover, kratom and cannabis, contain toxic or prohibited impurities, that must be remediated before the extracts can be used in production. These impurities cannot be removed by common purification methods used in traditional medicine processing steps.
In order to comply with regulations and guidelines (e.g., The European Medicines Agency), drug producers must keep the purity of their products above the regulated level. This level of remediating impurities must be done with a purification step such as chromatography.
The Most Cost-Efficient Chromatographic Solution
Natural extract downstream chains are typically focused on some basic steps. These include dry milling, or even extraction to a certain extent. Then the downstream moves to a final polishing step, and then dosing or packaging. Producers, who's downstream has no chromatographic step are missing out on high-value compounds that they could easily exploit, as they are working with products that contain those compounds either way.
Missing out on isolating these high-value compounds will result in a loss of potential revenue. By implementing chromatography in your downstream, you can process the hazardous waste that would have to be dealt with at the end of your purification chain and generate revenue at the same time.
Take a look at the graph below, comparing the costs of THC-remediated broad-spectrum CBD oil purification methods. Centrifugal partition chromatography is demonstrably the most cost-efficient solution, far more affordable than any other solution:
RotaChrom brings industrial-scale CPC solutions to businesses, researchers, CROs and CDMOs.
If you'd like to dive deeper, please fill in the form above, and grab your free copy of RotaChrom's 'Natural Extract Purification' white paper. The paper covers 4 in-depth chapters about CPC and LLC.
RotaChrom Technologies developed the world’s first industrial scale centrifugal partition chromatography technology solution. These liquid chromatography machines revolutionized purification by providing innovative, sustainable, and efficient industrial scale LC-CPC chromatography to customers all over the world in various industries, including pharmaceutical, nutraceutical and botanical extracts.
RotaChrom’s proven GMP compliant CPC designs are effective solutions when looking for a high-purity, high-capacity, cost-effective and environmentally conscious solution. RotaChrom, with its in-house research laboratory employing world class PhD chemists, engineers and leading business professionals on multiple continents, is the best partner in purification.
Our portfolio includes several products, which can help you scale your business from research to industry. Select between lab scale, pilot scale or industrial scale purification:
- The rCPC platform for pilot-scale purification tasks within a laboratory environment. It is ideal for all batch sizes, smaller or larger, or campaign type of research work, and continuous-batch production.
- The iCPC platform, which is the largest commercially available centrifugal partition Chromatography instrument in the world. It is designed for industrial-scale purification projects in continuous batch operation mode.
CPC offers many benefits compared to traditional chromatographic solutions.
HPLC, flash, supercritical fluid chromatography and traditional chromatographic are all outperformed by CPC. Without the need for silica gel or cartridges, and the benefit of easy, linear scalability, plus the solvent handling capacity demonstrably make CPC the most cost-efficient chromatography solution long-term.
