No silica

Silica, a thing of the past!

During the preparative-scale high performance liquid chromatography, separation is conducted through silica-based stationary phase, utilizing organic solvent based mobile phase. The most common issues are the compounds that are irreversibly bound in the system, and, as the result of pressure, silica degradation. Frequent silica regeneration cycle or replacement significantly increases the maintenance expenditures.

One of the ample benefits of the Rotachrom iCPC technology is that it is a sustainable approach by that it does not require the usage of expensive and polluting silica gel as it does not utilize any solid stationary phase in order to achieve crude purification.

The iCPC is the largest serialized centrifugal partition chromatographic platform in the world, designed for industrial-scale purification projects in continuous batch operation mode, with the capacity to process hundreds of kilograms per month of crude input material. Make 20kg+ end product each day more with flexible, affordable, robust, future-proof chromatography.

Rotachrom’s Centrifugal Partition Chromatography (CPC) technology requires far less solvent consumption than comparative methods. What’s more, a staggering 95% of the solvent material is recoverable and reusable in the system.

Instead of HPLC grade solvents, this iCPC system merely requires technical grade solvents to perform industrial scale GMP compliant precision separation.

Bidding farewell to silica: Our Zero Silica Gel principle throughout in the Purification Process means that the total consumables when applying an iCPC system, can be substantially reduced and could be even decimated if a RotaChrom’ tailor-made solvent recovery system is in place.

No more Silica Gel

Silica, a thing of the past!

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Lower OPEX, lower total cost of ownership

Additional benefits

Future-proof tech

Recycled solvents

Higher flow rates

Low consumable costs

No silica

Scalability